{"id":3432,"date":"2017-11-24T12:12:20","date_gmt":"2017-11-24T14:12:20","guid":{"rendered":"http:\/\/en-mol.icb.usp.br\/?page_id=3432"},"modified":"2026-07-21T12:30:29","modified_gmt":"2026-07-21T15:30:29","slug":"7-32-bone","status":"publish","type":"page","link":"https:\/\/mol-en.icb.usp.br\/index.php\/7-32-bone\/","title":{"rendered":"7-32 Bone"},"content":{"rendered":"<p><strong>BONE HISTOGENESIS<\/strong><\/p>\n<p><strong>Histogenesis<\/strong> designates the formation of a tissue. In the case of the bone tissue, this process is called <strong>osteogenesis<\/strong> or <strong>ossification<\/strong>.<br \/>\nThere are two basic types of bone histogenesis called intramembranous and endochondral ossification. In both processes the bone cells derive from mesenchymal cells. In humans, osteogenesis begins around the sixth and seventh weeks of embryonic development.<\/p>\n<p><strong>Intramembranous ossification<\/strong> happens inside a layer of mesenchyme \u2014 the embryonal connective tissue. It contains stem-cells that can give rise to various types of connective tissue \u2014 cartilage, bone, adipose tissue, etc. as well as blood cells.<br \/>\nIn various parts of the body, the mesenchyme is arranged as layers or membranes. The intramembranous ossification happens within some of these layers and gives rise to many flat bones, for example, most of the head bones. <\/p>\n<p>The second type of ossification \u2013 <strong>endochondral ossification<\/strong> \u2013  begins from cells of  connective tissue layers that cover cartilage pre-formed models of the future bones. The bone-forming cells gradually occupy the surface of the cartilage model as well cavities formed inside the models and constitute bone tissue. During the endochondral ossification the cartilaginous model is gradually replaced by bones tissue.<br \/>\nThis type of ossification originates most long bones as well as some other types of bones, such as the vertebrae.<\/p>\n<p><a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/7-33-2\/\">NEXT PAGE<\/a><\/p>\n<p><a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/7-31-bone\/\">PREVIOUS PAGE<\/a><\/p>\n<p><a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/7-0-bone\/\">MENU OF THIS CHAPTER<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>BONE HISTOGENESIS Histogenesis designates the formation of a tissue. In the case of the bone tissue, this process is called osteogenesis or ossification. There are two basic types of bone histogenesis called intramembranous and endochondral ossification. In both processes the bone cells derive from mesenchymal cells. In humans, osteogenesis begins around the sixth and seventh [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3432","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/3432","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/comments?post=3432"}],"version-history":[{"count":32,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/3432\/revisions"}],"predecessor-version":[{"id":23370,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/3432\/revisions\/23370"}],"wp:attachment":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/media?parent=3432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}