{"id":3432,"date":"2017-11-24T12:12:20","date_gmt":"2017-11-24T14:12:20","guid":{"rendered":"http:\/\/en-mol.icb.usp.br\/?page_id=3432"},"modified":"2025-10-24T18:47:01","modified_gmt":"2025-10-24T21:47:01","slug":"7-32-bone","status":"publish","type":"page","link":"https:\/\/mol-en.icb.usp.br\/index.php\/7-32-bone\/","title":{"rendered":"7-32 Bone"},"content":{"rendered":"<p><strong>BONE HISTOGENESIS<\/strong><\/p>\n<p>&#8220;Histogenesis&#8221; designates the formation of a tissue. In the case of the bone tissue, this process is also called <strong>osteogenesis<\/strong> or <strong>ossification<\/strong>.<\/p>\n<p>There are two basic modes of ossification: intramembranous ossification and endochondral ossification.<\/p>\n<p>Intramembranous ossification occurs from mesenchymal tissue \u2014 the embryonic connective tissue. It contains stem-cells that can give rise to various types of connective tissue \u2014 cartilage, bone, adipose tissue, etc. as well as blood cells.<\/p>\n<p>In various parts of the body, this mesenchyme is arranged in the form of a layers or membranes. The intramembranous ossification happens within these layers.<br \/>\nThis type of ossification primarily gives rise to the flat bones, for example, the flat bones of the skull.<\/p>\n<p>The second type of ossification \u2013 endochondral ossification \u2013 occurs during fetal life over models of bones made of cartilage. After the endochondral ossification process is complete, the cartilaginous skeleton gradually disappears and is replaced by the bony skeleton.<\/p>\n<p>This type of ossification gives rise to long bones and some other types of bones, such as vertebrae.<\/p>\n<p><a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/7-33-2\/\">NEXT PAGE<\/a><\/p>\n<p><a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/7-31-bone\/\">PREVIOUS PAGE<\/a><\/p>\n<p><a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/7-0-bone\/\">MENU OF THIS CHAPTER<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>BONE HISTOGENESIS &#8220;Histogenesis&#8221; designates the formation of a tissue. In the case of the bone tissue, this process is also called osteogenesis or ossification. There are two basic modes of ossification: intramembranous ossification and endochondral ossification. Intramembranous ossification occurs from mesenchymal tissue \u2014 the embryonic connective tissue. It contains stem-cells that can give rise to [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3432","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/3432","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/comments?post=3432"}],"version-history":[{"count":16,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/3432\/revisions"}],"predecessor-version":[{"id":16547,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/3432\/revisions\/16547"}],"wp:attachment":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/media?parent=3432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}