{"id":3362,"date":"2017-11-22T21:41:23","date_gmt":"2017-11-22T23:41:23","guid":{"rendered":"http:\/\/en-mol.icb.usp.br\/?page_id=3362"},"modified":"2026-05-13T23:03:11","modified_gmt":"2026-05-14T02:03:11","slug":"7-30-bone","status":"publish","type":"page","link":"https:\/\/mol-en.icb.usp.br\/index.php\/7-30-bone\/","title":{"rendered":"7-30 Bone"},"content":{"rendered":"<div class=\"su-row\">\n  <div class=\"su-column su-column-size-1-1\"><div class=\"su-column-inner su-u-clearfix su-u-trim\"> <strong>EPIPHYSEAL DISK &#8211; 7<\/strong> <\/div><\/div>\n<\/div>\n<div class=\"su-row\">\n<div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\">\nThe upper image shows the transition between the calcified cartilage zone and the ossification zone. A line indicates the boundary between the two zones.<br \/>\nThe area above the line is filled with calcified cartilage. It is easy to see that the the space below the line is occupied by another tissue: bone tissue that has been deposited over the calcified cartilage septa.<\/p>\n<p>Lower image<br \/>\nA higher magnification of the transitional area.<br \/>\nIn the final region of the calcified cartilage zone, the chondrocytes have undergone cell death, and their nuclei and cytoplasm have disintegrated.<br \/>\nMany sites previously occupied by chondrocytes are now empty (highlighted in green).<br \/>\nIn the lower part of the image: walls of cartilage extracellular matrix that surrounded cartilage cells are now covered by a thin layer of bone cells: osteoblasts, osteocytes (highlighted in pink). The newly produced bone matrix is highlighted in a darker tone of blue.<br \/>\nCartilages do not contain blood vessels. At the center of the image observe a blood vessel (highlighted in brown), that penetrated the cartilage to irrigate the bonethat is being formed. <\/p>\n<\/div><\/div>\n  <div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\"> <\/p>\n<p><img decoding=\"async\" src=\"https:\/\/mol-en.icb.usp.br\/wp-content\/uploads\/7-30-en.jpg\"\/><\/a> <\/p>\n<p>Epiphyseal disc. Staining: HE. Magnification: small.<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/mol-en.icb.usp.br\/wp-content\/uploads\/mouse-1.gif\"\/><\/a><\/p>\n<p><a href=\"javascript:void(0)\"><img decoding=\"async\" src=\" https:\/\/mol-en.icb.usp.br\/wp-content\/uploads\/7-30-B.jpg \" onmouseover=\"this.src=' https:\/\/mol-en.icb.usp.br\/wp-content\/uploads\/7-30-B-MO.jpg'\" onmouseout=\"this.src=' https:\/\/mol-en.icb.usp.br\/wp-content\/uploads\/7-30-B.jpg'\" \/><\/a><\/div>\n<p>Epiphyseal disc. Staining: HE. Magnification: medium.<\/a><\/p>\n<p><a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/7-31-bone\/\">NEXT PAGE<\/a><\/p>\n<p><a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/7-29-bone\/\">PREVIOUS PAGE<\/a><\/p>\n<p><a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/7-0-bone\/\">MENU OF THIS CHAPTER<\/a>\n<\/div>\n<\/div>\n<\/div>\n<p><\/body><br \/>\n<\/html> <\/div><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3362","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/3362","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/comments?post=3362"}],"version-history":[{"count":83,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/3362\/revisions"}],"predecessor-version":[{"id":22502,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/3362\/revisions\/22502"}],"wp:attachment":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/media?parent=3362"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}