{"id":2754,"date":"2017-09-18T20:03:12","date_gmt":"2017-09-18T23:03:12","guid":{"rendered":"http:\/\/en-mol.icb.usp.br\/?page_id=2754"},"modified":"2026-08-31T17:48:08","modified_gmt":"2026-08-31T20:48:08","slug":"4-19-connective-tissue","status":"publish","type":"page","link":"https:\/\/mol-en.icb.usp.br\/index.php\/4-19-connective-tissue\/","title":{"rendered":"4-19 Connective tissue"},"content":{"rendered":"<div class=\"su-row\">\n  <div class=\"su-column su-column-size-1-1\"><div class=\"su-column-inner su-u-clearfix su-u-trim\"> <strong>RESIDENT CELLS OF THE CONNECTIVE TISSUE<\/strong><\/p>\n<p>MACROPHAGE-1<\/div><\/div>\n<\/div>\n<div class=\"su-row\">\n  <div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\">\nMacrophages are cells derived from the monocytes, a type of blood leukocyte produced in the hematopoietic bone marrow.<br \/>\nCirculating monocytes can leave the blood by crossing the walls of blood vessels. After entering the tissues they develop into macrophages. They are often present in the connective tissue all over the body (not including the central nervous system). They become specially concentrated in various organs such as the liver, spleen, and lymph nodes.<br \/>\nMacrophages are specialized for <strong>phagocytosis<\/strong> and play an important role in the body&#8217;s defense. Together with the neutrophils they are considered <strong>&#8220;professional phagocytes&#8221;<\/strong> as compared to other cells that phagocyte occasionally or infrequently.<br \/>\nFurthermore, the macrophages contains many <strong>lysosomes<\/strong> which are important for digesting the material they engulf. They secrete several molecules that play important roles in the <strong>inflammatory process and the immune response<\/strong><br \/>\nMacrophages are spherical or flattened, depending on the place where the are settled. They are relatively large cells when compared to red blood cells or lymphocytes<br \/>\nThe cytoplasm of the macrophages stains pink with eosin and its spherical nucleus may be sometimes eccentric (meaning it is placed ouside of the cell center).<br \/>\n<strong>Recognizing a macrophage is not always easy in routine H&#038;E-stained preparations.<\/strong> Immunocytochemical techniques can better identify them using specific antibodies or protein markers.<br \/>\nAnother useful clue for identifying macrophages in tissue sections is to look for <strong>phagocytosed material<\/strong> within their cytoplasm. This is particularly helpful when examining isolated cells in connective tissue or in organs where macrophages are commonly found.<br \/>\nThe <strong>image<\/strong> shows sections of the liver of a laboratory animal that had been injected intravenously with a solution containing the dye carmine. Macrophages in the liver, also known as <strong>Kupffer cells<\/strong>, phagocytosed particles of the dye. These particles can be seen within the cytoplasm of the cells, indicated by arrows.<br \/>\nNotice that macrophages that had engulfed large amounts of dye have their nuclei displaced toward the cell periphery. The accumulation of phagocytosed material occupies much of the cytoplasm and appears to \u201cpush\u201d the nucleus toward the edge of the cell.<br \/>\n<div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\"><\/div><\/div> <\/p>\n<p><img decoding=\"async\" src=\" https:\/\/mol-en.icb.usp.br\/wp-content\/uploads\/4-20.jpg \" \/><\/a><\/p>\n<p>Macrophages in the liver. Staining: hematoxylin. Large magnification.<\/p>\n<\/p>\n<p><strong><br \/>\n<a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/4-20-connective-tissue\/\">NEXT PAGE<\/a><\/p>\n<p><a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/4-18-connective-tissue\/\">PREVIOUS PAGE<\/p>\n<p><a href= https:\/\/mol-en.icb.usp.br\/index.php\/4-0-connective-tissue\/\">MENU OF THIS CHAPTER<\/a><br \/>\n<\/div><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2754","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/2754","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/comments?post=2754"}],"version-history":[{"count":65,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/2754\/revisions"}],"predecessor-version":[{"id":25225,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/2754\/revisions\/25225"}],"wp:attachment":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/media?parent=2754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}