{"id":2723,"date":"2017-09-18T15:04:54","date_gmt":"2017-09-18T18:04:54","guid":{"rendered":"http:\/\/en-mol.icb.usp.br\/?page_id=2723"},"modified":"2026-08-31T15:14:23","modified_gmt":"2026-08-31T18:14:23","slug":"4-18-connective-tissue","status":"publish","type":"page","link":"https:\/\/mol-en.icb.usp.br\/index.php\/4-18-connective-tissue\/","title":{"rendered":"4-18 Connective tissue"},"content":{"rendered":"<div class=\"su-row\">\n<div class=\"su-column su-column-size-1-1\"><div class=\"su-column-inner su-u-clearfix su-u-trim\"> <strong>RESIDENT CELLS OF THE CONNECTIVE TISSUE<\/strong><\/p>\n<p>MAST CELL<br \/>\n<\/div><\/div>\n<\/div>\n<div class=\"su-row\">\n<div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\">\nThe mast cells, also called mastocytes, are large, round or oval-shaped cells that are often found close to blood vessels.<br \/>\nThey participate in inflammatory and allergic reactions by releasing several biologically active substances, including histamine and heparin that are stored in numerous cytoplasmic   vacuoles called granules.<br \/>\nThe nucleus is usually located near the center of the cell, and the cytoplasm contains many clearly defined granules. However, these granules are usually not well stained by routine hematoxylin and eosin (H&#038;E) staining. For this reason, mast cells are often difficult to recognize in routinely stained histological sections. They can be identified  with metachromatic dyes, such as toluidine blue, which stain their granules very well and with stains used to visualize elastic fibers, such as Weigert&#8217;s stain.<br \/>\nMetachromatic dyes are so called because they stain cellular structures a color slightly different from the original color of the dye. Mast cell granules, for example, stain purple instead of blue by toluidine blue.<br \/>\nThe image is of a whole-mount preparation of a small piece of a mesentery that was stained to demonstrate elastic fibers. The mast cell nucleus is not stained, but its cytoplasm is filled with granules.<br \/>\nThe thin fibrils are elastic fibers of the extracellular matrix.<\/p>\n<\/div><\/div>\n<div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\">\n<img decoding=\"async\" src=\" https:\/\/mol-en.icb.usp.br\/wp-content\/uploads\/4-18B.jpg \" \/><\/a><\/p>\n<p>Whole mount of mesentery. Staining: Weigert. Large magnification.<\/p>\n<p><strong><br \/>\n<a href=https:\/\/mol-en.icb.usp.br\/index.php\/4-19-connective-tissue\/\">NEXT PAGE<\/a><\/p>\n<p><a href=https:\/\/mol-en.icb.usp.br\/index.php\/4-17-connective-tissue\/\">PREVIOUS PAGE<\/a><\/p>\n<p><a href= https:\/\/mol-en.icb.usp.br\/index.php\/4-0-connective-tissue\/\">MENU OF THIS CHAPTER<\/a><\/p>\n<\/div><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2723","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/2723","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/comments?post=2723"}],"version-history":[{"count":51,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/2723\/revisions"}],"predecessor-version":[{"id":25124,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/2723\/revisions\/25124"}],"wp:attachment":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/media?parent=2723"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}