{"id":21375,"date":"2026-03-26T16:20:48","date_gmt":"2026-03-26T19:20:48","guid":{"rendered":"https:\/\/mol-en.icb.usp.br\/?page_id=21375"},"modified":"2026-07-29T17:24:42","modified_gmt":"2026-07-29T20:24:42","slug":"7-1-bone-2","status":"publish","type":"page","link":"https:\/\/mol-en.icb.usp.br\/index.php\/7-1-bone-2\/","title":{"rendered":"7-1 Bone"},"content":{"rendered":"<div class=\"su-row\">\n  <div class=\"su-column su-column-size-1-1\"><div class=\"su-column-inner su-u-clearfix su-u-trim\">  <div class=\"su-row\"><\/div>\n  <div class=\"su-column su-column-size-1-1\"><div class=\"su-column-inner su-u-clearfix su-u-trim\"><\/div><\/div> <strong> THE BASIC STRUCTURE OF BONES - 1 <\/strong> <\/div><\/div>\n<\/div>\n  <div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\"><\/div><\/div>\nBones are a type of connective tissue containing specialized resident cells derived from the mesenchyme and a hard  extracellular matrix.<br \/>\nThis matrix is quite unique, as it is formed by an organic portion and a mineralized portion.<br \/>\nMain features of the matrix:<br \/>\n- A predominance of type I collagen fibers in the organic matrix, as well as proteoglycans, glycoproteins and several other molecules, some of which exclusive to or characteristic of bones.<br \/>\n- The inorganic matrix is calcified due to the deposition of calcium phosphate on the collagen fibrils forming  crystals of hydroxyapatite.<br \/>\nAs collagen fibers stain well with eosin, the bone matrix appears pink in bone sections after staining them with H&E, unlike the cartilage matrix that stains bluish\/blue by hematoxylin.<\/p>\n<p><strong>Histological sections of bones and teeth<\/strong><br \/>\nHard tissues require special methodologies to obtain histological sections. Click on the links to examine some 0f them <a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/1-27-basic-concepts\/\">Peparation of hard tissues \u2013 bone and teeth \u2013 1 and <a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/1-28-basic-concepts\/\">Peparation of hard tissues \u2013 bone and teeth \u2013 2<\/p>\n<p><a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/7-2-bone\/\">NEXT PAGE<\/a><\/p>\n<p><a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/7-0-bone\/\">MENU OF THIS CHAPTER<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bones are a type of connective tissue containing specialized resident cells derived from the mesenchyme and a hard extracellular matrix. This matrix is quite unique, as it is formed by an organic portion and a mineralized portion. Main features of the matrix: &#8211; A predominance of type I collagen fibers in the organic matrix, as [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-21375","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/21375","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/comments?post=21375"}],"version-history":[{"count":67,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/21375\/revisions"}],"predecessor-version":[{"id":23586,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/21375\/revisions\/23586"}],"wp:attachment":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/media?parent=21375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}