{"id":21375,"date":"2026-03-26T16:20:48","date_gmt":"2026-03-26T19:20:48","guid":{"rendered":"https:\/\/mol-en.icb.usp.br\/?page_id=21375"},"modified":"2026-09-07T18:23:21","modified_gmt":"2026-09-07T21:23:21","slug":"7-1-bone-2","status":"publish","type":"page","link":"https:\/\/mol-en.icb.usp.br\/index.php\/7-1-bone-2\/","title":{"rendered":"7-1 Bone"},"content":{"rendered":"<div class=\"su-row\">\n  <div class=\"su-column su-column-size-1-1\"><div class=\"su-column-inner su-u-clearfix su-u-trim\">  <div class=\"su-row\"><\/div>\n  <div class=\"su-column su-column-size-1-1\"><div class=\"su-column-inner su-u-clearfix su-u-trim\"><\/div><\/div> <strong>BASIC STRUCTURE OF BONES - 1 <\/strong> <\/div><\/div>\n<\/div>\n  <div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\"><\/div><\/div>\nBone is a type of connective tissue composed of <strong>specialise resident cells<\/strong> derived from the mesenchyme and a <strong>hard  extracellular matrix. <\/strong><br \/>\nThe bone matrix is quite unique becaused it has an <strong>organic component<\/strong> and a <strong>mineralized component<\/strong>.<br \/>\nMain features of the bone matrix:<br \/>\n<strong>Organic matrix<\/strong> - It contains predominantly type I collagen fibers, as well as proteoglycans, glycoproteins and several other molecules, some of which exclusive to or characteristic of bones.<br \/>\n<strong>Inorganic matrix<\/strong> -  This matrix is calcified as a result of the deposition of calcium phosphate on the collagen fibrils forming crystals of hydroxyapatite which turn the bone into a hard tissue.<\/p>\n<p>As collagen fibers stain well with eosin, its extracellular matrix appears pink in sections stained with H&E. <\/p>\n<p><strong>Histological sections of bones and teeth<\/strong><br \/>\nHard tissues require special methodologies to obtain histological sections. Click on the links to examine some of them <a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/1-27-basic-concepts\/\">Peparation of hard tissues \u2013 bone and teeth \u2013 1 and <a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/1-28-basic-concepts\/\">Peparation of hard tissues \u2013 bone and teeth \u2013 2<\/p>\n<p><a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/7-2-bone\/\">NEXT PAGE<\/a><\/p>\n<p><a href=\"https:\/\/mol-en.icb.usp.br\/index.php\/7-0-bone\/\">MENU OF THIS CHAPTER<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bone is a type of connective tissue composed of specialise resident cells derived from the mesenchyme and a hard extracellular matrix. The bone matrix is quite unique becaused it has an organic component and a mineralized component. Main features of the bone matrix: Organic matrix &#8211; It contains predominantly type I collagen fibers, as well [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-21375","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/21375","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/comments?post=21375"}],"version-history":[{"count":75,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/21375\/revisions"}],"predecessor-version":[{"id":25636,"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/pages\/21375\/revisions\/25636"}],"wp:attachment":[{"href":"https:\/\/mol-en.icb.usp.br\/index.php\/wp-json\/wp\/v2\/media?parent=21375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}